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Antioxidants in the prevention of atherosclerosis: the importance of proper patient selection.

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  • Author(s): Levy Y; Blum S; Levy AP
  • Source:
    Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2009 Oct; Vol. 28 (5), pp. 581-2. Date of Electronic Publication: 2009 May 22.
  • Publication Type:
    Comment; Letter
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE
    • Publication Information:
      Publication: <2004->: Kidlington, Oxford, U.K. : Elsevier
      Original Publication: Edinburgh ; New York : Churchill Livingstone, c1982-
    • Subject Terms:
      Diabetes Mellitus* ; Patient Selection*; Antioxidants/*administration & dosage ; Cardiovascular Diseases/*prevention & control ; Haptoglobins/*genetics ; Vitamin E/*administration & dosage; Dietary Supplements ; Genetic Predisposition to Disease ; Humans ; Oxidative Stress ; Randomized Controlled Trials as Topic
    • Abstract:
      We wish to comment on the recent publication by Katiski and Manes. We absolutely agree with the reviewers that there has been no consistent protective effect of any single antioxidant or combination against cardiovascular morbidity and mortality. However, one reason why antioxidant trials may have failed to show clinical benefit in these studies may be related to inappropriate patient selection. Thus, we would like to present a recent prospective double blind placebo controlled study (ICARE), which assessed potential cardiovascular benefit from vitamin E in a subgroup of patients with both Diabetes Mellitus (DM) and the Haptoglobin (Hp) 2-2 genotype-agroup with very high oxidative stress. We believe that groups with evidence of a significant pro-oxidative and pro-inflammatory milieu such as the diabetic patients with the Hp 2-2 genotype, may benefit from antioxidants. Thus, better identification of such sub-groups, which will respond favorably to treatment with antioxidants is worthy of investigation.
    • Comments:
      Comment on: Clin Nutr. 2009 Feb;28(1):3-9. (PMID: 19042058)
    • Accession Number:
      0 (Antioxidants)
      0 (Haptoglobins)
      1406-18-4 (Vitamin E)
    • Publication Date:
      Date Created: 20090526 Date Completed: 20100201 Latest Revision: 20091013
    • Publication Date:
      20221216
    • Accession Number:
      10.1016/j.clnu.2009.04.012
    • Accession Number:
      19464773