Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Haptoglobin phenotype, angiogenic factors, and preeclampsia risk.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0370476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6868 (Electronic) Linking ISSN: 00029378 NLM ISO Abbreviation: Am J Obstet Gynecol Subsets: MEDLINE
    • Publication Information:
      Publication: <2005->: New York : Elsevier
      Original Publication: St. Louis.
    • Subject Terms:
    • Abstract:
      Objective: We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF).
      Study Design: Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum.
      Results: Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07-4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07-5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes.
      Conclusion: Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.
      (Copyright © 2012 Mosby, Inc. All rights reserved.)
    • References:
      Lancet. 2002 Jun 1;359(9321):1877-90. (PMID: 12057549)
      Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):341-7. (PMID: 18032779)
      Atherosclerosis. 2002 Apr;161(2):441-6. (PMID: 11888529)
      J Biol Chem. 2009 Oct 30;284(44):30395-407. (PMID: 19740759)
      Am J Obstet Gynecol. 2002 Jul;187(1):127-36. (PMID: 12114900)
      Clin Chem. 1996 Oct;42(10):1589-600. (PMID: 8855140)
      J Clin Invest. 2003 Mar;111(5):649-58. (PMID: 12618519)
      Endocrine. 2010 Oct;38(2):303-8. (PMID: 20972727)
      J Vasc Surg. 2011 Jan;53(1):266-7; author reply 267. (PMID: 21184946)
      Obstet Gynecol. 2000 Jan;95(1):24-8. (PMID: 10636496)
      Br J Obstet Gynaecol. 1984 Feb;91(2):128-32. (PMID: 6696858)
      J Clin Invest. 1993 Mar;91(3):977-85. (PMID: 7680672)
      Circulation. 2010 Aug 3;122(5):478-87. (PMID: 20644016)
      Int J Lab Hematol. 2007 Apr;29(2):92-110. (PMID: 17474882)
      Int J Gynaecol Obstet. 1998 May;61(2):127-33. (PMID: 9639216)
      J Med Genet. 2003 Mar;40(3):214-6. (PMID: 12624142)
      Hypertension. 2012 Jul;60(1):239-46. (PMID: 22647886)
      Clin Chem Lab Med. 2006;44(8):924-8. (PMID: 16879055)
      Diabetes Care. 2004 Apr;27(4):925-30. (PMID: 15047650)
      Antioxid Redox Signal. 2010 Feb;12(2):293-304. (PMID: 19659435)
      Ethiop Med J. 1990 Jan;28(1):9-14. (PMID: 2307159)
      Hypertension. 2005 Dec;46(6):1263-9. (PMID: 16246973)
    • Grant Information:
      UL1 TR000005 United States TR NCATS NIH HHS; Canada CAPMC CIHR; P01 HD030367-16 United States HD NICHD NIH HHS; P01 HD030367 United States HD NICHD NIH HHS; UL1 RR024153 United States RR NCRR NIH HHS
    • Accession Number:
      0 (Angiogenesis Inducing Agents)
      0 (Antigens, CD)
      0 (ENG protein, human)
      0 (Endoglin)
      0 (Haptoglobins)
      0 (Membrane Proteins)
      0 (PIGF protein, human)
      0 (Receptors, Cell Surface)
      EC (FLT1 protein, human)
      EC (Vascular Endothelial Growth Factor Receptor-1)
    • Publication Date:
      Date Created: 20120221 Date Completed: 20120521 Latest Revision: 20211021
    • Publication Date:
    • Accession Number:
    • Accession Number:
    • Accession Number: