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Haptoglobin phenotype, angiogenic factors, and preeclampsia risk.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0370476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6868 (Electronic) Linking ISSN: 00029378 NLM ISO Abbreviation: Am J Obstet Gynecol Subsets: MEDLINE
    • Publication Information:
      Publication: <2005->: New York : Elsevier
      Original Publication: St. Louis.
    • Subject Terms:
    • Abstract:
      Objective: We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF).
      Study Design: Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum.
      Results: Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07-4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07-5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes.
      Conclusion: Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.
      (Copyright © 2012 Mosby, Inc. All rights reserved.)
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    • Grant Information:
      UL1 TR000005 United States TR NCATS NIH HHS; Canada CAPMC CIHR; P01 HD030367-16 United States HD NICHD NIH HHS; P01 HD030367 United States HD NICHD NIH HHS; UL1 RR024153 United States RR NCRR NIH HHS
    • Accession Number:
      0 (Angiogenesis Inducing Agents)
      0 (Antigens, CD)
      0 (ENG protein, human)
      0 (Endoglin)
      0 (Haptoglobins)
      0 (Membrane Proteins)
      0 (PIGF protein, human)
      0 (Receptors, Cell Surface)
      EC 2.7.10.1 (FLT1 protein, human)
      EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
    • Publication Date:
      Date Created: 20120221 Date Completed: 20120521 Latest Revision: 20211021
    • Publication Date:
      20220902
    • Accession Number:
      PMC3319170
    • Accession Number:
      10.1016/j.ajog.2012.01.009
    • Accession Number:
      22340942