Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort.

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Author(s): Weissgerber TL;Weissgerber TL; McGee PL; Myatt L; Hauth JC; Varner MW; Wapner RJ; Thorp JM Jr; Mercer BM; Peaceman AM; Ramin SM; Samuels P; Sciscione AC; Harper M; Saade G; Sorokin Y
Source:
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2014 Nov; Vol. 27 (17), pp. 1728-33. Date of Electronic Publication: 2014 Jan 13.
Publication Type:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Language:
English

Additional Information
- Corporate Authors:
  Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
- Source:
  Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE
- Publication Information:
  Publication: London : Informa Healthcare
  Original Publication: Boca Raton : Parthenon Pub. Group, c2002-
- Subject Terms:
  Haptoglobins/*analysis ; Uterine Artery/*diagnostic imaging; Adult ; Antioxidants/therapeutic use ; Ascorbic Acid/therapeutic use ; Cohort Studies ; Ethnicity/statistics & numerical data ; Female ; Humans ; Phenotype ; Pre-Eclampsia/prevention & control ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy Trimester, Second/blood ; Racial Groups ; Ultrasonography, Doppler, Color ; Ultrasonography, Prenatal ; Vitamin E/therapeutic use ; Young Adult
- Abstract:
  Objective: The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy.
  Methods: We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks' gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups.
  Results: Hp phenotype did not significantly influence the odds of having any notch (p = 0.32), bilateral notches (p = 0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks' gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p = 0.25).
  Conclusions: Hp phenotype is not associated with abnormal UAD at 17 weeks' gestation or with persistent notching at 24 weeks.
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- Grant Information:
  HD36801 United States HD NICHD NIH HHS; UG1 HD027869 United States HD NICHD NIH HHS; U10 HD034136 United States HD NICHD NIH HHS; U10 HD040485 United States HD NICHD NIH HHS; HD40485 United States HD NICHD NIH HHS; HD40560 United States HD NICHD NIH HHS; U10 HD040560 United States HD NICHD NIH HHS; U10 HD040512 United States HD NICHD NIH HHS; U01 HD036801 United States HD NICHD NIH HHS; U10 HD053118 United States HD NICHD NIH HHS; UL1 RR024989 United States RR NCRR NIH HHS; UL1 TR000005 United States TR NCATS NIH HHS; U10 HD040500 United States HD NICHD NIH HHS; P01 HD030367 United States HD NICHD NIH HHS; U10 HD040544 United States HD NICHD NIH HHS; UL1 RR024153 United States RR NCRR NIH HHS; UG1 HD034116 United States HD NICHD NIH HHS; HD27869 United States HD NICHD NIH HHS; HD34136 United States HD NICHD NIH HHS; UG1 HD040560 United States HD NICHD NIH HHS; HD53118 United States HD NICHD NIH HHS; K12 HD065987 United States HD NICHD NIH HHS; UG1 HD053097 United States HD NICHD NIH HHS; HD27860 United States HD NICHD NIH HHS; UG1 HD027915 United States HD NICHD NIH HHS; Canada CAPMC CIHR; HD40512 United States HD NICHD NIH HHS; UG1 HD040544 United States HD NICHD NIH HHS; UG1 HD034208 United States HD NICHD NIH HHS; M01 RR00080 United States RR NCRR NIH HHS; UG1 HD040512 United States HD NICHD NIH HHS; HD40545 United States HD NICHD NIH HHS; U10 HD034116 United States HD NICHD NIH HHS; HD21410 United States HD NICHD NIH HHS; U10 HD027869 United States HD NICHD NIH HHS; U10 HD027917 United States HD NICHD NIH HHS; HD34116 United States HD NICHD NIH HHS; U10 HD027915 United States HD NICHD NIH HHS; UG1 HD040545 United States HD NICHD NIH HHS; UG1 HD040485 United States HD NICHD NIH HHS; U10 HD027860 United States HD NICHD NIH HHS; HD40500 United States HD NICHD NIH HHS; U10 HD034208 United States HD NICHD NIH HHS; U10 HD053097 United States HD NICHD NIH HHS; HD34208 United States HD NICHD NIH HHS; HD27915 United States HD NICHD NIH HHS; UG1 HD040500 United States HD NICHD NIH HHS; HD27917 United States HD NICHD NIH HHS; U10 HD021410 United States HD NICHD NIH HHS; M01 RR000080 United States RR NCRR NIH HHS; U10 HD036801 United States HD NICHD NIH HHS; HD53097 United States HD NICHD NIH HHS; U10 HD040545 United States HD NICHD NIH HHS; K12HD065987 United States HD NICHD NIH HHS; HD40544 United States HD NICHD NIH HHS
- Contributed Indexing:
  Investigator: J Roberts; S Caritis; T Kamon; M Cotroneo; D Fischer; P Reed; S Quinn; V Morby; F Porter; R Silver; J Miller; K Hill; DJ Rouse; A Northen; P Files; J Grant; M Wallace; K Bailey; S Bousleiman; R Alcon; K Saravia; F Loffredo; A Bayless; C Perez; M Lake; M Talucci; K Boggess; K Dorman; J Mitchell; K Clark; S Timlin; J Bailit; C Milluzzi; W Dalton; C Brezine; D Bazzo; K Leveno; J Sheffield; L Moseley; M Santillan; K Buentipo; J Price; LS Hermann; C Melton; Y Gloria-McCutchen; B Espino; M Dinsmoor; T Matson-Manning; G Mallett; S Blackwell; K Cannon; S Lege-Humbert; Z Spears; M Carpenter; J Tillinghast; M Seebeck; J Iams; F Johnson; S Fyffe; C Latimer; S Frantz; J Wylie; M Talucci; M Hoffman; J Benson; Z Reid; C Tocci; P Meis; M Swain; J Tolosa; W Smith; L Davis; E Lairson; S Butcher; S Maxwell; D Fisher; J Moss; B Stratton; G Hankins; J Brandon; C Nelson-Becker; G Olson; L Pacheco; G Norman; S Blackwell; P Lockhart; D Driscoll; M Dombrowski; E Thom; R Clifton; T Boekhoudt; L Leuchtenburg; V Pemberton; J Cutler; W Barouch; C Spong; S Tolivaisa; GD Anderson
  Keywords: Ethnicity; haptoglobin; pregnancy; race; vascular resistance; women
- Accession Number:
  0 (Antioxidants)
  0 (Haptoglobins)
  1406-18-4 (Vitamin E)
  PQ6CK8PD0R (Ascorbic Acid)
- Publication Date:
  Date Created: 20131219 Date Completed: 20150803 Latest Revision: 20211203
- Publication Date:
  20221216
- Accession Number:
  PMC4096612
- Accession Number:
  10.3109/14767058.2013.876622
- Accession Number:
  24345080

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