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Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort.

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  • Additional Information
    • Corporate Authors:
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: Boca Raton : Parthenon Pub. Group, c2002-
    • Subject Terms:
    • Abstract:
      Objective: The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy.
      Methods: We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks' gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups.
      Results: Hp phenotype did not significantly influence the odds of having any notch (p = 0.32), bilateral notches (p = 0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks' gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p = 0.25).
      Conclusions: Hp phenotype is not associated with abnormal UAD at 17 weeks' gestation or with persistent notching at 24 weeks.
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    • Grant Information:
      HD36801 United States HD NICHD NIH HHS; UG1 HD027869 United States HD NICHD NIH HHS; U10 HD034136 United States HD NICHD NIH HHS; U10 HD040485 United States HD NICHD NIH HHS; HD40485 United States HD NICHD NIH HHS; HD40560 United States HD NICHD NIH HHS; U10 HD040560 United States HD NICHD NIH HHS; U10 HD040512 United States HD NICHD NIH HHS; U01 HD036801 United States HD NICHD NIH HHS; U10 HD053118 United States HD NICHD NIH HHS; UL1 RR024989 United States RR NCRR NIH HHS; UL1 TR000005 United States TR NCATS NIH HHS; U10 HD040500 United States HD NICHD NIH HHS; P01 HD030367 United States HD NICHD NIH HHS; U10 HD040544 United States HD NICHD NIH HHS; UL1 RR024153 United States RR NCRR NIH HHS; UG1 HD034116 United States HD NICHD NIH HHS; HD27869 United States HD NICHD NIH HHS; HD34136 United States HD NICHD NIH HHS; UG1 HD040560 United States HD NICHD NIH HHS; HD53118 United States HD NICHD NIH HHS; K12 HD065987 United States HD NICHD NIH HHS; UG1 HD053097 United States HD NICHD NIH HHS; HD27860 United States HD NICHD NIH HHS; UG1 HD027915 United States HD NICHD NIH HHS; Canada CAPMC CIHR; HD40512 United States HD NICHD NIH HHS; UG1 HD040544 United States HD NICHD NIH HHS; UG1 HD034208 United States HD NICHD NIH HHS; M01 RR00080 United States RR NCRR NIH HHS; UG1 HD040512 United States HD NICHD NIH HHS; HD40545 United States HD NICHD NIH HHS; U10 HD034116 United States HD NICHD NIH HHS; HD21410 United States HD NICHD NIH HHS; U10 HD027869 United States HD NICHD NIH HHS; U10 HD027917 United States HD NICHD NIH HHS; HD34116 United States HD NICHD NIH HHS; U10 HD027915 United States HD NICHD NIH HHS; UG1 HD040545 United States HD NICHD NIH HHS; UG1 HD040485 United States HD NICHD NIH HHS; U10 HD027860 United States HD NICHD NIH HHS; HD40500 United States HD NICHD NIH HHS; U10 HD034208 United States HD NICHD NIH HHS; U10 HD053097 United States HD NICHD NIH HHS; HD34208 United States HD NICHD NIH HHS; HD27915 United States HD NICHD NIH HHS; UG1 HD040500 United States HD NICHD NIH HHS; HD27917 United States HD NICHD NIH HHS; U10 HD021410 United States HD NICHD NIH HHS; M01 RR000080 United States RR NCRR NIH HHS; U10 HD036801 United States HD NICHD NIH HHS; HD53097 United States HD NICHD NIH HHS; U10 HD040545 United States HD NICHD NIH HHS; K12HD065987 United States HD NICHD NIH HHS; HD40544 United States HD NICHD NIH HHS
    • Contributed Indexing:
      Investigator: J Roberts; S Caritis; T Kamon; M Cotroneo; D Fischer; P Reed; S Quinn; V Morby; F Porter; R Silver; J Miller; K Hill; DJ Rouse; A Northen; P Files; J Grant; M Wallace; K Bailey; S Bousleiman; R Alcon; K Saravia; F Loffredo; A Bayless; C Perez; M Lake; M Talucci; K Boggess; K Dorman; J Mitchell; K Clark; S Timlin; J Bailit; C Milluzzi; W Dalton; C Brezine; D Bazzo; K Leveno; J Sheffield; L Moseley; M Santillan; K Buentipo; J Price; LS Hermann; C Melton; Y Gloria-McCutchen; B Espino; M Dinsmoor; T Matson-Manning; G Mallett; S Blackwell; K Cannon; S Lege-Humbert; Z Spears; M Carpenter; J Tillinghast; M Seebeck; J Iams; F Johnson; S Fyffe; C Latimer; S Frantz; J Wylie; M Talucci; M Hoffman; J Benson; Z Reid; C Tocci; P Meis; M Swain; J Tolosa; W Smith; L Davis; E Lairson; S Butcher; S Maxwell; D Fisher; J Moss; B Stratton; G Hankins; J Brandon; C Nelson-Becker; G Olson; L Pacheco; G Norman; S Blackwell; P Lockhart; D Driscoll; M Dombrowski; E Thom; R Clifton; T Boekhoudt; L Leuchtenburg; V Pemberton; J Cutler; W Barouch; C Spong; S Tolivaisa; GD Anderson
      Keywords: Ethnicity; haptoglobin; pregnancy; race; vascular resistance; women
    • Accession Number:
      0 (Antioxidants)
      0 (Haptoglobins)
      1406-18-4 (Vitamin E)
      PQ6CK8PD0R (Ascorbic Acid)
    • Publication Date:
      Date Created: 20131219 Date Completed: 20150803 Latest Revision: 20211203
    • Publication Date:
      20220301
    • Accession Number:
      PMC4096612
    • Accession Number:
      10.3109/14767058.2013.876622
    • Accession Number:
      24345080