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Haptoglobin duplicon, hemoglobin, and vitamin C: analyses in the british women's heart and health study and Caerphilly prospective study.

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  • Additional Information
    • Source:
      Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : New York, NY : Hindawi Pub. Corp.
      Original Publication: Chichester ; New York : Wiley, c1983-
    • Subject Terms:
    • Abstract:
      Background: Haptoglobin acts as an antioxidant by limiting peroxidative tissue damage by free hemoglobin. The haptoglobin gene allele Hp2 comprises a 1.7 kb partial duplication. Relative to allele Hp1, Hp2 carriers form protein multimers, suboptimal for hemoglobin scavenging.
      Objective: To examine the association of haptoglobin genotype with a range of phenotypes, with emphasis on vitamin C and hemoglobin levels.
      Methods: We applied a quantitative PCR assay for the duplication junction to two population cohorts including 2747 British women and 1198 British men. We examined the association of haptoglobin duplicon copy number with hemoglobin and vitamin C and used the copy number to complete a phenome scan.
      Results: Hemoglobin concentrations were greater in those with Hp2,2 genotype, in women only (Hp1,1 13.45 g/dL, Hp1,2 13.49 g/dL, Hp2,2 13.61 g/dL; P = 0.002), though statistically there was no evidence of a difference between the sexes (z value = 1.2, P = 0.24). Haptoglobin genotype was not associated with vitamin C or any other phenotype in either cohort.
      Conclusions: Our results do not support association of haptoglobin genotype with vitamin C or with other phenotypes measured in two population cohorts. The apparent association between haptoglobin genotype and hemoglobin in the women's cohort merits further investigation.
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    • Grant Information:
      MC_UU_12013/8 United Kingdom MRC_ Medical Research Council; PG/13/66/30442 United Kingdom BHF_ British Heart Foundation; G0600705 United Kingdom MRC_ Medical Research Council; MR/K002767/1 United Kingdom MRC_ Medical Research Council
    • Accession Number:
      0 (HP protein, human)
      0 (Haptoglobins)
      0 (Hemoglobins)
      PQ6CK8PD0R (Ascorbic Acid)
    • Publication Date:
      Date Created: 20141220 Date Completed: 20150731 Latest Revision: 20220129
    • Publication Date:
      20220129
    • Accession Number:
      PMC4265517
    • Accession Number:
      10.1155/2014/529456
    • Accession Number:
      25525287