Anti-oxidative treatment with vitamin E improves peripheral vascular function in patients with diabetes mellitus and Haptoglobin 2-2 genotype: A double-blinded cross-over study.

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Author(s): Alshiek JA;Alshiek JA;Alshiek JA; Dayan L; Dayan L; Dayan L; Asleh R; Asleh R; Asleh R; Blum S; Blum S; Levy AP; Levy AP; Jacob G; Jacob G; Jacob G
Source:
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2017 Sep; Vol. 131, pp. 200-207. Date of Electronic Publication: 2017 Jul 13.
Publication Type:
Journal Article; Randomized Controlled Trial
Language:
English

Additional Information
- Source:
  Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8227 (Electronic) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res Clin Pract Subsets: MEDLINE
- Publication Information:
  Publication: 1993- : Limerick : Elsevier Scientific Publishers
  Original Publication: Amsterdam : Elsevier Science Publishers B.V., c1985-
- Subject Terms:
  Antioxidants/*therapeutic use ; Diabetes Mellitus/*drug therapy ; Haptoglobins/*genetics ; Peripheral Vascular Diseases/*prevention & control ; Vitamin E/*therapeutic use; Adult ; Antioxidants/pharmacology ; Cohort Studies ; Cross-Over Studies ; Double-Blind Method ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Oxidative Stress/genetics ; Vitamin E/administration & dosage ; Vitamin E/pharmacology
- Abstract:
  Vascular dysfunction in both conduit arteries and small vessels is a major contributor to the development of cardiovascular disease (CVD) in diabetes mellitus (DM). In diabetes there is a process of systemic chronic inflammation accompanied by high oxidative stress causing a subsequent decrease in vascular reactivity and negatively affect the metabolic processes responsible for functioning of the microvasculature. Vitamin E is classified as an antioxidant due to its ability to scavenge lipid radicals and terminate oxidative chain reactions. We conducted a double-blinded cross-over study with vitamin E versus placebo in individuals with type 2DM and the Hp2-2 genotype and assessed different aspects of peripheral vascular function in these patients. Twenty patients completed the study with 10 individuals in each study cohort. We were able to show significant improvement of indirect indices of vascular function following 8weeks of treatment with vitamin E. This improvement was consistent for weeks even after stopping the vitamin E treatment. We concluded that a pharmacogenomic rationale utilizing the Hp genotype might potentially provide cardiovascular benefit with vitamin E.
  (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Contributed Indexing:
  Keywords: Anti-oxidant; Blood flow; Diabetes mellitus; Haptoglobin; Vascular function; Vitamin E
- Accession Number:
  0 (Antioxidants)
  0 (Haptoglobins)
  1406-18-4 (Vitamin E)
- Publication Date:
  Date Created: 20170801 Date Completed: 20180209 Latest Revision: 20181202
- Publication Date:
  20221216
- Accession Number:
  10.1016/j.diabres.2017.06.026
- Accession Number:
  28759833

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