The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.

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Author(s): Dalan R;Dalan R;Dalan R;Dalan R; Liuh Ling G; Liuh Ling G
Source:
European journal of preventive cardiology [Eur J Prev Cardiol] 2018 Sep; Vol. 25 (14), pp. 1502-1519. Date of Electronic Publication: 2018 May 25.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Language:
English

Additional Information
- Source:
  Publisher: Oxford University Press Country of Publication: England NLM ID: 101564430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-4881 (Electronic) Linking ISSN: 20474873 NLM ISO Abbreviation: Eur J Prev Cardiol Subsets: MEDLINE
- Publication Information:
  Publication: 2021- : [Oxford] : Oxford University Press
  Original Publication: London : Sage
- Subject Terms:
  Polymorphism, Genetic*; Diabetes Mellitus, Type 1/*genetics ; Diabetes Mellitus, Type 2/*genetics ; Diabetic Angiopathies/*genetics ; Haptoglobins/*genetics ; Oxidative Stress/*genetics; Animals ; Antioxidants/administration & dosage ; Clinical Decision-Making ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/metabolism ; Diabetic Angiopathies/prevention & control ; Dietary Supplements ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Oxidative Stress/drug effects ; Phenotype ; Precision Medicine ; Prognosis ; Risk Factors ; Vitamin E/administration & dosage
- Abstract:
  Introduction and background Haptoglobin (Hp) is considered to be an antioxidant and protective against cardiovascular complications. Polymorphisms in the Hp gene interact with diabetes mellitus to affect the risk of vascular complications. Methods We review the updated literature about the protean role of Hp and Hp genotypes spanning genomics, molecular, translational and clinical studies. We searched Pubmed, SCOPUS and Google Scholar for all articles using the keywords: haptoglobin and/or haptoglobin polymorphism and diabetes. We review the diverse Hp genotypes, phenotypes and the impact on diabetes complications, including lessons from animal models and in vitro models. We describe the clinical studies on the associations of Hp genotypes with vascular complications in type 1 and type 2 diabetes comprehensively. We review the studies looking at vitamin E supplementation in a personalized manner in Hp2-2 diabetes individuals. Results and conclusion Hp genotypes have evolved as a result of deletions in the traditional Hp genes. The Hp genotypes have been associated with microvascular and macrovascular complications in type 1 diabetes mellitus but the association in type 2 diabetes is more consistent with cardiovascular complications. A preferential benefit of vitamin E and other antioxidants in the Hp2-2 genotype for cardiovascular complications in type 2 diabetes has been seen presumably secondary to interaction with high-density lipoprotein function. Hence, the Hp genotype can be used to personalize antioxidant therapeutics in diabetes patients. These results need to be corroborated in large, global, pragmatic, prospective, cardiovascular outcome trials in type 2 diabetes patients.
- Comments:
  Comment in: Eur J Prev Cardiol. 2018 Sep;25(14):1498-1501. (PMID: 30103628)
- Contributed Indexing:
  Keywords: Haptoglobin; diabetes mellitus; haptoglobin polymorphism
- Accession Number:
  0 (Antioxidants)
  0 (HP protein, human)
  0 (Haptoglobins)
  1406-18-4 (Vitamin E)
- Publication Date:
  Date Created: 20180526 Date Completed: 20191125 Latest Revision: 20191125
- Publication Date:
  20221216
- Accession Number:
  10.1177/2047487318776829
- Accession Number:
  29799294

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