Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Haptoglobin Genotype Is a Determinant of Hemoglobin Adducts and Vitamin E Content in HDL.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE
    • Publication Information:
      Publication: <2019>-: London, United Kingdom : Hindawi Limited
      Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]-
    • Subject Terms:
    • Abstract:
      Haptoglobin (Hp) is an abundant hemoglobin- (Hb-) binding serum protein and a constituent of the HDL proteome. In man, there exists a common polymorphism at the Hp locus with two common alleles defined by the presence (Hp 2 allele) or absence (Hp 1 allele) of a 1.7 kb in-frame partial duplication of exons 3 and 4 of the Hp gene. Numerous studies have demonstrated that the Hp 2-2 genotype is associated with a 3-5-fold increase in vascular disease among individuals with diabetes mellitus (DM). Increased Hp-Hb complex has been shown to be associated with the HDL of Hp 2-2 DM individuals. Hb-associated HDL has been proposed to result in the oxidation of HDL and the consumption of antioxidants in HDL, such as vitamin E, rendering the HDL further susceptible to oxidation. In this study, we set out to identify proteins which become cross-linked to Hb in HDL and to measure vitamin E in HDL as a function of the Hp genotype. We report on the identification of a novel 72 kd Hb reactive species which is cross-linked to HDL and demonstrate that vitamin E in HDL is decreased in Hp 2-2 DM individuals.
    • References:
      J Am Coll Cardiol. 2002 Dec 4;40(11):1984-90. (PMID: 12475459)
      Diabetes. 2008 Oct;57(10):2794-800. (PMID: 18599520)
      Circ Res. 2006 Dec 8;99(12):1419-25. (PMID: 17082477)
      J Biol Chem. 2014 Jun 6;289(23):16313-25. (PMID: 24778180)
      Sci Rep. 2014 Feb 13;4:4086. (PMID: 24522390)
      Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):341-7. (PMID: 18032779)
      Acta Diabetol. 2016 Apr;53(2):243-50. (PMID: 26002590)
      Blood. 2001 Dec 15;98(13):3693-8. (PMID: 11739174)
      Proc Natl Acad Sci U S A. 1966 Sep;56(3):974-8. (PMID: 5230192)
      Int J Vasc Med. 2012;2012:918267. (PMID: 22611498)
      Diabetes Care. 2004 Nov;27(11):2767. (PMID: 15505023)
      PLoS One. 2016 Oct 7;11(10 ):e0164264. (PMID: 27716784)
      Cholesterol. 2015;2015:296417. (PMID: 26634153)
      Br J Pharmacol. 2012 Nov;167(6):1177-94. (PMID: 22725625)
      J Biol Chem. 2009 Jul 3;284(27):18292-301. (PMID: 19433579)
    • Accession Number:
      0 (Haptoglobins)
      0 (Lipoproteins, HDL)
      1406-18-4 (Vitamin E)
    • Publication Date:
      Date Created: 20180612 Date Completed: 20181024 Latest Revision: 20190723
    • Publication Date:
    • Accession Number:
    • Accession Number:
    • Accession Number: