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Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats

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  • Additional Information
    • Publication Information:
      Bethesda, MD: American Physiological Society, 2001.
    • Publication Date:
      2001
    • Original Material:
      INIST-CNRS
    • Abstract:
      We tested the hypothesis that endothelin acting through the endothelial ETB receptor subtype and the nitric oxide (NO) pathway accounts for reduced myogenic reactivity of the renal resistance vasculature during pregnancy. Small renal arteries (100-200 μm) were isolated from virgin and midterm pregnant rats when gestational renal hyperfiltration and vasodilation are maximal in this species. Myogenic reactivity (the adjustment of arterial diameter in response to a change in transmural pressure) was assessed with a pressurized myograph system. A rapid increase in transmural pressure from 60 to 80 mmHg resulted in a 2.4% diameter increase in vessels from virgin compared with an 8.1% increase in arteries from midgestation rats (n = 8 each, P < 0.05). Thus myogenic reactivity is markedly reduced during pregnancy. Incubation with the NO synthase inhibitors, an ETB receptor subtype antagonist (RES-701-1), the nonselective ETA/B receptor blocker (SB-209670), or endothelial removal abrogated the reduced myogenic reactivity of vessels from gravid rats without affecting myogenic reactivity in arteries from virgin animals. Thus the endothelium mediates the reduced myogenic reactivity of small renal arteries of midgestation rats most likely through the ETB receptor subtype and NO pathway.
    • File Description:
      text
    • Author Affiliations:
      Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh and Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213, United States
      Department of Cell Biology and Physiology, University of Pittsburgh and Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213, United States
    • ISSN:
      0363-6119
    • Rights:
      Copyright 2001 INIST-CNRS
      CC BY 4.0
      Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
    • Notes:
      Vertebrates : cardiovascular system
    • Accession Number:
      edscal.1086970