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First Trimester Uric Acid and Adverse Pregnancy Outcomes

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  • Additional Information
    • Publication Information:
      Basingstoke: Nature Publishing Group, 2011.
    • Publication Date:
      2011
    • Original Material:
      INIST-CNRS
    • Abstract:
      BACKGROUND The association of elevated serum uric acid with the development of hypertension is established outside of pregnancy. We investigated whether first trimester uric acid was associated with the development of the following: gestational hypertension or pre-eclampsia, these outcomes stratified by presence of hyperuricemia at delivery since this denotes more severe disease, preterm birth, or small for gestational age (SGA). METHODS Uric acid was measured in 1,541 banked maternal plasma samples from a prior prospective cohort study that were collected at a mean gestational age of 9.0 (± 2.5) weeks. Polytomous regressions were performed and adjusted for parity and prepregnancy body mass index (BMI). RESULTS First trimester uric acid in the highest quartile (>3.56 mg/dl) compared to lowest three quartiles was associated with an increased risk of developing pre-eclampsia (adjusted odds ratio (OR) = 1.82; 95% confidence interval (CI),1.03―3.21) but not gestational hypertension. In women with hypertensive disease complicated by hyperuricemia at delivery, high first trimester uric acid was associated with a 3.22-fold increased risk of hyperuricemic gestational hypertension (HU) and a 3.65-fold increased risk of hyperuricemic pre-eclampsia (HPU). High first trimester uric acid was not associated with gestational hypertension or pre-eclampsia without hyperuricemia (H or HP) at delivery, preterm birth, or SGA. In women who developed hypertensive disease, elevated uric acid at delivery was only partly explained by elevated uric acid in the first trimester (r2 = 0.23). CONCLUSIONS First trimester elevated uric acid was associated with later preeclampsia and more strongly with pre-eclampsia and gestational hypertension with hyperuricemia.
    • File Description:
      text
    • Author Affiliations:
      Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
      Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
      Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
    • ISSN:
      0895-7061
    • Rights:
      Copyright 2015 INIST-CNRS
      CC BY 4.0
      Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
    • Notes:
      Cardiology. Circulatory system

      Gynecology. Andrology. Obstetrics
    • Accession Number:
      edscal.24080543