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Low Placental Growth Factor Across Pregnancy Identifies a Subset of Women With Preterm Preeclampsia: Type 1 Versus Type 2 Preeclampsia?

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  • Additional Information
    • Publication Information:
      Hagerstown, MD: Lippincott Williams & Wilkins, 2012.
    • Publication Date:
      2012
    • Original Material:
      INIST-CNRS
    • Abstract:
      Preeclampsia is a heterogeneous syndrome affecting 3% to 5% of all pregnancies. An imbalance of the antiangiogenic and proangiogenic factors, soluble receptor fms-like tyrosine kinase 1 and placental growth factor (PGF), is thought to contribute to the pathophysiology of preeclampsia. Maternal plasma PGF and soluble receptor fms-like tyrosine kinase 1 were quantified by specific immunoassays in cross-sectional samples from 130 preeclamptic subjects and 342 normotensive controls at delivery and longitudinally in samples from 50 women who developed preeclampsia and 250 normotensive controls. Among women who developed preeclampsia, 46% (n=23) evidenced a pattern of consistently low maternal PGF across pregnancy below the lower 95% CI of controls from 15 weeks' gestation to term. In contrast, the remaining 54% (n=27) of women who developed preeclampsia had maternal PGF concentrations similar to or above (n=7) those of normotensive controls. Subjects with low PGF across pregnancy who developed preeclampsia evidenced significantly higher blood pressure in early pregnancy (P<0.05) and, after diagnosis, earlier gestational age at delivery (P<0.05) and more preterm birth (P<0.05) compared with preeclamptic patients with high PGF. A significant subset of women who develop preeclampsia show evidence of consistently low PGF across pregnancy. Low PGF with preeclampsia was associated with preterm delivery compared with preeclamptic patients with high PGF. Identifying women with consistently low plasma PGF during pregnancy may provide a greater understanding of preeclampsia pathophysiology and may provide more focused research and clinical activities.
    • File Description:
      text
    • Author Affiliations:
      Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, United States
      R.E.G., Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, United States
      Clinical and Translational Research, University of Pittsburgh, Pittsburgh, PA, United States
      Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, United States
      Abbott Laboratories, Abbott Park, IL, United States
      Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States
    • ISSN:
      0194-911X
    • Rights:
      Copyright 2015 INIST-CNRS
      CC BY 4.0
      Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
    • Notes:
      Cardiology. Circulatory system

      Gynecology. Andrology. Obstetrics
    • Accession Number:
      edscal.26002816